Ciba Foundation Symposium 48 - Purine and Pyrimidine Metabolism

Content:
Chapter 1 Chairman's Opening Remarks (pages 1–2): R. W. E. Watts
Chapter 2 Purine and Pyrimidine Metabolism: Pathways, Pitfalls and Perturbations (pages 3–21): J. Frank Henderson, Jeffrey K. Lowe and Jerzy Barankiewicz
Chapter 3 Microbial Models and Regulatory Elements in the Control of Purine Metabolism (pages 23–41): Josepha S. Gots, Charles E. Benson, Bjarne Jochimsen and K. R. Koduri
Chapter 4 Molecular Nature of Enzyme Regulation in Purine Biosynthesis (pages 43–64): James B. Wyngaarden and Edward W. Holmes
Chapter 5 Genetic Heterogeneity at the Locus for Hypoxanthine?Guanine Phosphoribosyltransferase (pages 65–81): William L. Nyhan
Chapter 6 Factors in the Pathogenesis of the Brain Damage and Anaemia in the Lesch?Nyhan Syndrome (pages 83–96): R.O. Mckeran
Chapter 7 Hypoxanthine?Guanine Phosphoribosyltransferase Activity in Individual Erythrocytes: Autoradiographic Studies in Heter Ozygotes (pages 97–104): B. T. Emmerson, R. B. Gordon and L. A. Johnson
Chapter 8 Purine Biosynthesis in Mutant Mammalian Cells (pages 105–126): Gabrielle H. Reem
Chapter 9 Purine and Pyrimidine Nucleotides in Some Mutant Human Lymphoblasts (pages 127–142): G. Nuki, K. Astrini, D. Brenton, M. Cruikshank, J. Lever and J. E. Seegmiller
Chapter 10 Superactivity of Phosphoribosylpyrophosphate Synthetase, due to Feedback Resistance, Causing Purine Overproduction and Gout (pages 143–164): Oded Sperling, Pnina Boer, Sara Brosh, Esther Zoref and Andre de Vries
Chapter 11 Dietary Feedback Regulation of Purine and Pyrimidine Biosynthesis in Man (pages 165–178): N. Zollner and W. Grobner
Chapter 12 Implications of Disorders of Purine Metabolism for the Kidney and the Urinary Tract (pages 179–206): Andre de Vries and Oded Sperling
Chapter 13 The Role of de novo Purine Synthesis in Lymphocyte Transformation (pages 207–224): A. C. Allison, T. Hovi, R. W. E. Watts and A. D. B. Webster
Chapter 14 Purine Metabolism and Control of Cell Proliferation (pages 225–248): Tapani Hovi, Tapani Hovi, Anthony C. Allison, Kari O. Raivio and Antti Vaheri
Chapter 15 The Effect of Adenosine on Lymphoid Cell Proliferation and Antibody Formation (pages 249–276): J. Edwin Seegmiller, T. Watanabe and Max H. Schreier
Chapter 16 Characterization of Human Adenosine Deaminase (pages 277–293): William N. Kelley, Peter E. Daddona and Martin B. van der Weyden
Chapter 17 The Purinergic Nerve Hypothesis (pages 295–314): Geoffrey Burnstock
Chapter 18 Inherited Metabolic Disease: Prospects for the Future in Both Basic and Clinical Research (pages 315–355): R. W. E. Watts